The Solution Improvement of Quercetin Using Spontaneous Emulsification Systems
Quercetin has been used for health promotion for instance anti-bacterial, anti-inflammatory, anti-coagulative, antineoplastic and antioxidant. The poorly water-soluble quercetin has been a significant problem of bioavailability for oral administration. The objective of this study was to improve the quercetin solubility by spontaneous emulsion formulation (SEF). SEF was fabricated by dissolved quercetin in mixture of polyoxyl 35 castor oil, diethylene glycol monoethy ether, caprylic/capric glyceride. The solid-SEF was obtained by incorporation with solid carrier adsorbent (magnesium aluminometasilicate). The photon correlation spectroscopy was used to determine the emulsion size of diluted SEF and solid-SEF. The power X-ray diffraction and differential scanning calorimetry were also employed to elucidate the powder of solid-SEF compared with unmodified quercetin. The dissolution profiled at 120 min of unmodified quercetin, SEF and solid-SEF was about 2%, 77% and 89%, respectively.